ASPARAGUS RACEMOSUS MONOGRAPH PDF

Asparagus racemosus, traditionally known as shatavari means “who medicines , lists Asparagus racemosus as part of .. Thomson M. Herbal Monograph –. A. racemosus is common throughout Sri Lanka, India and the Himalayas. It grows one to two metres tall and prefers to take root in. monographs of the most popular herbs in the US based on the original India’s Asparagus species, A. racemosus, or shatavari, which means ‘she who has.

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The dried roots of the plant are used as drug. The roots are said to be tonic and diuretic and galactgogue, the drug has ulcer healing effect probably via strenthening the mucosal resistance or cytoprotection. It has also been identified as one of the drugs to control the symotoms of AIDS. However, no scintific proof justify aborementioned uses of root extract of A. Recently few reports are available demonstrating beneficial effects of alcoholic and water extract of the roots of A.

The present artical includes the detailed exploration of pharmacological properties of the root extract of A.

ASPARAGUS RACEMOSUS

It is considered both a general tonic and a female reproductive tonic. Shatavari is the main Ayurvedic rejuvenative tonic for the female, as is Withania for the male. Asparagus racemosus family Asparagaceae also known by the name Shatavari is one of the well known drugs in Ayurveda, effective in treating madhur rasam, madhur vipakam, seet-veeryam, som rogam, chronic fever and internal monigraph [1][2].

This herb is highly effective in problems related with female reproductive system. Reports indicate that the pharmacological activities of A. A study of ancient classical Ayurvedic literature asparragus several therapeutic attributes for the root of A.

Beneficial effects of the root of A. The major active constituents of A. Shatavarin IV has been reported to display significant activity as an inhibitor of core Golgi enzymes transferase in cell free assays and recently to exhibit immuno-modulation activity against specific T-dependent antigens in immuno compromised animals [9]. Some plants parts are given in Figure 1. It was botanically described in [12]. Due to its multiple uses, the demand for A.

Due to destructive harvesting, combined with habitat destruction, and deforestation, the plant is now considered endangered in its natural habitat. Shatawari has different names in the different Indian languages, such as Shatuli, Vrishya and other terms.

In Nepal, it is called Kurilo. The leaves are like pine needles, small and uniform and flowers are white and have small spikes. This plant belongs to the genus Asparagus which has recently moved from the sub family Asparagae in the family Liliaceae to a newly created family Asparagaceae.

Its habitat is common at low altitudes in shade and in tropical climates throughout Asia, Australia and Africa. Out of several species of Asparagus grown in India, A. Shatvari is known monograpy possess a wide range of photochemical constituents which are mentioned below. Racemosud of the structures have been drawn in Figure 2. The root extract of A. Ahmednagar has been shown facemosus increase milk production in females complaining of dificient milk secretion [37].

Gradual decrease in milk secretion, on racemoss of the drug suggested that the increase in milk secretion was due to drug theraphy only and not due to any psychological asparaguz. In awparagus form of a commercial preparation, lactare TTK Pharma, Chennai is reported to enhance milk output in women complaining of scantly breast milk, on the 5th day after delivery [38].

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A significant increase in milk yield has also increase growth of mammary glands, alveolar tissue and acini in guinea pigs [39]. However, Sharma et al. The rwcemosus has attributed to the action of released corticoteroids or an increase in prolactin [42]. Shatavari was found to relive most of the symptoms in majority of the patients. It has been found to maintain the continuity and thickness of asprin treated gastric mucosa with a significant increase in mucosal main.

Aqueous extract was administered orally to experimental animals of biological, physical and chemical stressors. A model of cisplatin induced alteration in racemksus motility was used to test the ability of extract to exert a normalising effect, irrespective or direction of pathological change.

The extract reversed the effects of cisplatin on gastric emptying and also normalized cisplatin-induced intestinal hyper motility [47]. Chloramphenicol was used for comparison [48]. An aqueous solution of the crude alcoholic extract of the roots exhibited an inhibitory effect of the growth of Eintamoeba histolytica in vitro [49]. The powdered dried root of A. Oral administration of powdered dried root of A.

Its action is reported to be comparable with that of the synthetic dopamine antagonist metoclopromide [50]. The juice of fresh root of A. In addition to antiulcerogenic activity of A. Demonstrated similar effects of fresh root juice of A.

Various extract from the root of A. These actions were found to be similar to that of acetylcholine and were blocked by atropine, suggesting a cholinergic mechanism of action [54].

However no effect was observed on isolate rectus abdominus. Inspite of cholinergic activity of A. These extract also inhibited contraction induced by spasmogens like acetylcholine, barium chloride and 5- hydroxytryptamine where as alcoholic extract was found to produce a specific block of pitocin induced contraction. On the other hand petroleum ether as well as ether extract of the powdered roots did not produce any uterine activity.

It indicates the presence of some particular substance in the alcoholic extract which specifically block pitiocin sensitive receptor through not other in the uterus [54]. Confirming the Shatavari receptor can be used as uterin sedative. Further, a glycosides, Shatavarin 1, isolated from the roots of A.

Asparagus racemosus monograph pdf merge

Aqueous and ethanolic extract of A. The LC 50 was found to be 0. The activites were attributed to the presence of terpenoids, steroids and saponins in the extract [57]. Alcoholic extract of root of A.

Alcoholic extract of the root of A. The extract was found to produce hypotension in cats, which was blocked by atropine, indicating cholinergic mechanism of action.

The extract also produced congestion and complete stasis of blood flow in mesentric vessels of mice and rat, slight increase in the bleeding time and no effect on clotting time was obseved on i. Neither stimulant nor depressant action of lactrae on central nervous system has been reported in albino mice [63][64]. Shatavari did not produce catalepsy in experimental rats, even with massive oral doses, suggesting that its action may be asparaggus the blood-brain barrier, similar to that of metoclopromide.

Intra-abdominal sepsis is major causes of mortality following trauma and bowel surgery. Immunomodulating property of A.

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Oral administration of decotion of powdered root of A. Parcentage mortality of A. The immunoadjuvant potential of A. Immunostimulation was evaluated using serological and hematological parameters. Results indicate that the mnograph animals did show significant increase in antibody titre as compared to untreated raxemosus after change. Applications of test material as potential immunoadjuvant bring less morbidity and mortality to experimental animals [67] — [69].

However, it did show some antiamoebic effect in rats [49]. Asparagu administration of higher doses of all extracts did not produce only abnorbility in behavior pattern of mice and rat [54].

The possible antioxidant effects of crude extract and purified aqueous fraction of A. Gama radiation in those rays of Gray, induced lipid peroxidation as assessed by the formation of thiobarbituric acid reactive substances and lipid rqcemosus.

Asparagus racemosus monograph | THULIR SIDDHA –

Using an effective ssparagus of Gray antioxidant effect of A. Both the crude extract as well as P 3 fraction significantly inhibited lipid peroxidation and protein oxidation. The antioxidant effect of P 3 fraction was more pronounced against lipid peroxidation, as assessed by thiobarbituric acid reactive substance formation, while that of crude extract was more effective in inhibiting proteins oxidation [9][26][70][71].

The ethanolic extract of A. The ionic chemistry of urine was attered by ethylene glycol, which elevated the urinary concentration of crucial ions viz. The ethanolic extract, however, significantly reduced the elevated level of these ions in urine.

Also, it elevated the urinary concentration of magnesium, which is considered as one of the inhibitor of crystallization [72]. Methanolic extract of A. Pups to mother exposed to A. The live pup showed significant decrease in body weight and length, and delay of various development parameters when compared to respective control group.

Adaptogenic drugs are those which are useful as anti-stress agents by promoting non-specific resistance of the body. Although, the adaptogenic effect of A. Hence, the present investigation evaluates the antidepressant effect of MAR standardized to saponins Rats were given methanolic extract of roots of A.

Plant profile, phytochemistry and pharmacology of Asparagus racemosus (Shatavari): A review

In behavioral experiments, MAR increased the number of head twitches produced by 5-HTP and increased clonidine-induced aggressive behavior indicating facilitatory effect on both serotonergic and adrenergic systems respectively.

Thus, MAR has significant antidepressant activity and this effect is probably mediated through the serotonergic, noradrenergic systems and augmentation of antioxidant defenses [74]. Furthermore, ACE was effective at reducing inflammatory damage induced by chronic TPA exposure and evoked a significant inhibition of vascular permeability induced by acetic acid in mice [75].

MAR also significantly reversed scopolamine and sodium nitrite-induced increase in transfer latency on elevated plus maze indicating anti-amnesic activity. Further, MAR dose-dependently inhibited acetylcholinesterase enzyme in specific brain regions prefrontal cortex, hippocampus and hypothalamus. Aspargus, MAR showed nootropic and anti-amnesic activities in the models tested and these effects may probably be monogrwph through augmentation of cholinergic system due to its anti-cholinesterase activity.

Post-trial asparaghs of Convolvulus pluricaulis C. Hippocampal regions associated with the learning and memory functions showed dose dependent increase in AChE activity in Carbonic anhydrase 1 with A.